β-Elemene Reverses Chemoresistance of Breast Cancer Cells by Reducing Resistance Transmission via Exosomes | Zendy

Jun Zhang | Zendy; Heda Zhang | Zendy; Yufeng Yao | Zendy; Shanliang Zhong | Zendy; Jian Zhao | Zendy; Jin Tang | Zendy

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β-Elemene Reverses Chemoresistance of Breast Cancer Cells by Reducing Resistance Transmission via Exosomes

Author(s) -

Jun Zhang,

Heda Zhang,

Yufeng Yao,

Shanliang Zhong,

Jian Zhao,

Jin Tang

Publication year - 2015

Publication title -

cellular physiology and biochemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.486

H-Index - 87

eISSN - 1421-9778

pISSN - 1015-8987

DOI - 10.1159/000430191

Subject(s) - microvesicles , exosome , microrna , elemene , pten , cancer research , multiple drug resistance , biology , mcf 7 , drug resistance , cancer , cancer cell , pi3k/akt/mtor pathway , apoptosis , signal transduction , microbiology and biotechnology , gene , biochemistry , genetics , human breast

Currently, exosomes that act as mediators of intercellular communication are being researched extensively. Our previous studies confirmed that these exosomes contain microRNAs (miRNAs) that could alter chemo-susceptibility, which is partly attributed to the successful intercellular transfer of multidrug resistance (MDR)-specific miRNAs. We also confirmed that β-elemene could influence MDR-related miRNA expression and regulate the expression of the target genes PTEN and Pgp, which may lead to the reversal of the chemoresistant breast cancer (BCA) cells. We are the first to report these findings, and we propose the following logical hypothesis: β-elemene can mediate MDR-related miRNA expression in cells, thereby affecting the exosome contents, reducing chemoresistance transmission via exosomes, and reversing the drug resistance of breast cancer cells.

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