PRDX6 Protects ARPE-19 Cells from Oxidative Damage via PI3K/AKT Signaling | Zendy

Xu Zha | Zendy; Guojiu Wu | Zendy; Xueying Zhao | Zendy; Liqiong Zhou | Zendy; Hong Zhang | Zendy; Jinghua Li | Zendy; Linkun Ma | Zendy; Yuanping Zhang | Zendy

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PRDX6 Protects ARPE-19 Cells from Oxidative Damage via PI3K/AKT Signaling

Author(s) -

Xu Zha,

Guojiu Wu,

Xueying Zhao,

Liqiong Zhou,

Hong Zhang,

Jinghua Li,

Linkun Ma,

Yuanping Zhang

Publication year - 2015

Publication title -

cellular physiology and biochemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.486

H-Index - 87

eISSN - 1421-9778

pISSN - 1015-8987

DOI - 10.1159/000430186

Subject(s) - oxidative stress , protein kinase b , apoptosis , pi3k/akt/mtor pathway , annexin , microbiology and biotechnology , chemistry , flow cytometry , oxidative phosphorylation , programmed cell death , western blot , biology , biochemistry , gene

Oxidative stress that damages cells of the retinal pigment epithelium (RPE) can cause the development of hereditary retinal disease (HRD). PRDX6, which is a member of the PRDX family, is essential for removing metabolic free radicals from the body. However, the effect of PRDX6 on oxidative stress in HRD remains unknown. In this study, we sought to investigate the role of PRDX6 in oxidative stress-induced HRD in ARPE-19 cells and the molecular mechanism involved.

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