RP105 Protects Against Apoptosis in Ischemia/Reperfusion-Induced Myocardial Damage in Rats by Suppressing TLR4-Mediated Signaling Pathways | Zendy

Jun Yang | Zendy; Xin Guo | Zendy; Jian Yang | Zendy; Jiawang Ding | Zendy; Song Li | Zendy; Rui Yang | Zendy; Zhixing Fan | Zendy; Chaojun Yang | Zendy

Open Access

RP105 Protects Against Apoptosis in Ischemia/Reperfusion-Induced Myocardial Damage in Rats by Suppressing TLR4-Mediated Signaling Pathways

Author(s) -

Jun Yang,

Xin Guo,

Jian Yang,

Jiawang Ding,

Song Li,

Rui Yang,

Zhixing Fan,

Chaojun Yang

Publication year - 2015

Publication title -

cellular physiology and biochemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.486

H-Index - 87

eISSN - 1421-9778

pISSN - 1015-8987

DOI - 10.1159/000430180

Subject(s) - tunel assay , apoptosis , tlr4 , reperfusion injury , signal transduction , ischemia , medicine , western blot , pharmacology , microbiology and biotechnology , cancer research , chemistry , biology , biochemistry , gene

Myocardial apoptosis is heavily implicated in the myocardial damage caused by ischemia-reperfusion (I/R). Toll-like receptor 4 (TLR4) is a potent inducer of these apoptotic cascades. In contrast, the radioprotective 105 kDa protein (RP105) is a specific negative regulator of TLR4 signaling pathways. However, the precise mechanisms by which RP105 inhibits myocardium apoptosis via TLR4-associated pathways during I/R is not fully understood.

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