Transcription Factor Egr1 is Involved in High Glucose-Induced Proliferation and Fibrosis in Rat Glomerular Mesangial Cells | Zendy

Dan Wang | Zendy; Meiping Guan | Zendy; Zongji Zheng | Zendy; Wenqi Li | Zendy; Fuping Lyv | Zendy; Ruoyu Pang | Zendy; Yaoming Xue | Zendy

Open Access

Transcription Factor Egr1 is Involved in High Glucose-Induced Proliferation and Fibrosis in Rat Glomerular Mesangial Cells

Author(s) -

Dan Wang,

Meiping Guan,

Zongji Zheng,

Wenqi Li,

Fuping Lyv,

Ruoyu Pang,

Yaoming Xue

Publication year - 2015

Publication title -

cellular physiology and biochemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.486

H-Index - 87

eISSN - 1421-9778

pISSN - 1015-8987

DOI - 10.1159/000430177

Subject(s) - egr1 , gene silencing , growth factor , transforming growth factor , biology , ctgf , chromatin immunoprecipitation , endocrinology , medicine , transfection , cell growth , transcription factor , gene expression , cancer research , cell culture , promoter , gene , biochemistry , genetics , receptor

Backgroud: Diabetic nephropathy is one of the most frequent causes of end-stage renal disease and is associated with proliferation of glomerular mesangial cells (MCs) and excessive production of the extracellular matrix (ECM). Several studies have shown that early growth response factor 1 (Egr1) plays a key role in renal fibrosis by regulating the expression of genes encoding ECM components. However, whether Egr1 also contributes to diabetic nephropathy is unclear.

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