Inhibition of Notch Signaling Promotes the Adipogenic Differentiation of Mesenchymal Stem Cells Through Autophagy Activation and PTEN-PI3K/AKT/mTOR Pathway | Zendy

Baoquan Song | Zendy; Ying Chi | Zendy; Xue Li | Zendy; Wenjing Du | Zendy; Zhibo Han | Zendy; Jianjian Tian | Zendy; Juanjuan Li | Zendy; Fang Chen | Zendy; He-he Wu | Zendy; Li-xin Han | Zendy; Shihong Lu | Zendy; Yizhou Zheng | Zendy; Zhongchao Han | Zendy

Open Access

Inhibition of Notch Signaling Promotes the Adipogenic Differentiation of Mesenchymal Stem Cells Through Autophagy Activation and PTEN-PI3K/AKT/mTOR Pathway

Author(s) -

Baoquan Song,

Ying Chi,

Xue Li,

Wenjing Du,

Zhibo Han,

Jianjian Tian,

Juanjuan Li,

Fang Chen,

He-he Wu,

Li-xin Han,

Shihong Lu,

Yizhou Zheng,

Zhongchao Han

Publication year - 2015

Publication title -

cellular physiology and biochemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.486

H-Index - 87

eISSN - 1421-9778

pISSN - 1015-8987

DOI - 10.1159/000430167

Subject(s) - pi3k/akt/mtor pathway , autophagy , adipogenesis , notch signaling pathway , microbiology and biotechnology , pten , protein kinase b , chemistry , mesenchymal stem cell , cancer research , signal transduction , biology , apoptosis , biochemistry

The Notch signaling pathway is implicated in a broad range of developmental processes, including cell fate decisions. This study was designed to determine the role of Notch signaling in adipogenic differentiation of human bone marrow derived MSCs (BM-MSCs).

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