Ultra Low Dose Delta 9-Tetrahydrocannabinol Protects Mouse Liver from Ischemia Reperfusion Injury | Zendy

Edith Hochhauser | Zendy; Eylon Lahat | Zendy; Maya Sultan | Zendy; Orit Pappo | Zendy; Maayan Waldman | Zendy; Yosef Sarne | Zendy; Asher Shainberg | Zendy; Mordechai Gutman | Zendy; Michal Safran | Zendy; Ziv Ben Ari | Zendy

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Ultra Low Dose Delta 9-Tetrahydrocannabinol Protects Mouse Liver from Ischemia Reperfusion Injury

Author(s) -

Edith Hochhauser,

Eylon Lahat,

Maya Sultan,

Orit Pappo,

Maayan Waldman,

Yosef Sarne,

Asher Shainberg,

Mordechai Gutman,

Michal Safran,

Ziv Ben Ari

Publication year - 2015

Publication title -

cellular physiology and biochemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.486

H-Index - 87

eISSN - 1421-9778

pISSN - 1015-8987

DOI - 10.1159/000430165

Subject(s) - pharmacology , oxidative stress , reperfusion injury , medicine , liver injury , tunel assay , proinflammatory cytokine , ischemia , apoptosis , cannabinoid , endocrinology , chemistry , inflammation , receptor , biochemistry , immunohistochemistry

Ischemia/reperfusion (I/R) injury is the main cause of both primary graft dysfunction and primary non-function of liver allografts. Cannabinoids has been reported to attenuate myocardial, cerebral and hepatic I/R oxidative injury. Delta-9-tetrahydrocannabinol (THC), a cannabinoid agonist, is the active components of marijuana. In this study we examined the role of ultralow dose THC (0.002mg/kg) in the protection of livers from I/R injury. This extremely low dose of THC was previously found by us to protect the mice brain and heart from a variety of insults.

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