PDK1 Activity Regulates Proliferation, Invasion and Growth of Hemangiomas | Zendy

Ningning Zheng | Zendy; Xudong Ding | Zendy; Amy Sun | Zendy; Rabita Jahan | Zendy

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PDK1 Activity Regulates Proliferation, Invasion and Growth of Hemangiomas

Author(s) -

Ningning Zheng,

Xudong Ding,

Amy Sun,

Rabita Jahan

Publication year - 2015

Publication title -

cellular physiology and biochemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.486

H-Index - 87

eISSN - 1421-9778

pISSN - 1015-8987

DOI - 10.1159/000430159

Subject(s) - protein kinase b , cancer research , pi3k/akt/mtor pathway , matrigel , cell growth , signal transduction , small hairpin rna , microbiology and biotechnology , biology , angiogenesis , cell culture , gene knockdown , biochemistry , genetics

Hemangiomas are common vascular endothelial cell tumors. Abnormally activated PI3K/Akt signaling pathway is one of the most important biological characteristics of Hemangioma. 3-phosphoinositide-dependent kinase 1(PDK1), an upstream protein of Akt, regulates the activity of Akt and its downstream kinases. The objective of this study is to explore the effect of PDK1 on malignant vascular tumors and their cell signaling mechanism in mice.

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