Acetylcholine Attenuated TNF-α-Induced Apoptosis in H9c2 Cells: Role of Calpain and the p38-MAPK Pathway | Zendy

Ming Zhao | Zendy; Yang Yang | Zendy; XueYuan Bi | Zendy; XiaoJiang Yu | Zendy; Hang-Huan Jia | Zendy; Huanle Fang | Zendy; Weijin Zang | Zendy

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Acetylcholine Attenuated TNF-α-Induced Apoptosis in H9c2 Cells: Role of Calpain and the p38-MAPK Pathway

Author(s) -

Ming Zhao,

Yang Yang,

XueYuan Bi,

XiaoJiang Yu,

Hang-Huan Jia,

Huanle Fang,

Weijin Zang

Publication year - 2015

Publication title -

cellular physiology and biochemistry

Language(s) - English

Resource type - Journals

eISSN - 1421-9778

pISSN - 1015-8987

DOI - 10.1159/000430157

Subject(s) - calpastatin , calpain , p38 mitogen activated protein kinases , microbiology and biotechnology , apoptosis , mapk/erk pathway , tumor necrosis factor alpha , chemistry , caspase , phosphorylation , biology , programmed cell death , endocrinology , biochemistry , enzyme

Previous studies have shown that inflammation is associated with excessive activation of calpains. Acetylcholine (ACh) has been reported to inhibit pro-inflammatory cytokine release and protect against cardiomyocyte injury. However, there is no direct evidence regarding whether ACh can regulate calpains to exert cardioprotection. To this end, we investigated the effect of ACh on tumour necrosis factor alpha (TNF-α)-induced cardiomyocyte injury and further explored the underlying mechanism.

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