Proliferation and Cytokine Production of Human Mesangial Cells Stimulated by Secretory IgA Isolated from Patients with IgA Nephropathy | Zendy

Yan Liang | Zendy; Junjun Zhang | Zendy; Yali Zhou | Zendy; Guolan Xing | Zendy; Guoqiang Zhao | Zendy; Zhangsuo Liu | Zendy

Open Access

Proliferation and Cytokine Production of Human Mesangial Cells Stimulated by Secretory IgA Isolated from Patients with IgA Nephropathy

Author(s) -

Yan Liang,

Junjun Zhang,

Yali Zhou,

Guolan Xing,

Guoqiang Zhao,

Zhangsuo Liu

Publication year - 2015

Publication title -

cellular physiology and biochemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.486

H-Index - 87

eISSN - 1421-9778

pISSN - 1015-8987

DOI - 10.1159/000430151

Subject(s) - mesangial cell , nephropathy , immunoglobulin a , mesangium , cytokine , mesangial proliferative glomerulonephritis , immunology , proinflammatory cytokine , immune system , glomerulonephritis , medicine , biology , endocrinology , inflammation , immunoglobulin g , kidney , diabetes mellitus

IgA nephropathy (IgAN) is the most common form of primary glomerulonephritis, and often aggravates by mucosal infection. Secretory IgA (SIgA) is the dominant immunoglobulin in mucosal immunity, and is deposited in the mesangium in IgAN. The biological effects of SIgA on mesangial cells are poorly understood.

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