Open AccessPGE2 Modulates GABAA Receptors via an EP1 Receptor-Mediated Signaling Pathway
Author(s) -
Guang Yang,
Wenhao Dong,
Changlong Hu,
YanAi Mei
Publication year - 2015
Publication title -
cellular physiology and biochemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.486
H-Index - 87
eISSN - 1421-9778
pISSN - 1015-8987
DOI - 10.1159/000430143
Subject(s) - gabaa receptor , gabaa rho receptor , receptor , agonist , chemistry , downregulation and upregulation , microbiology and biotechnology , pharmacology , biology , endocrinology , biochemistry , gene
PGE2 is one of the most abundant prostanoids in mammalian tissues, but its effect on neuronal receptors has not been well investigated. This study examines the effect of PGE2 on GABAA receptor currents in rat cerebellar granule neurons.
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