Periostin Mediates TGF-β-Induced Epithelial Mesenchymal Transition in Prostate Cancer Cells | Zendy

Qingfeng Hu | Zendy; Shijun Tong | Zendy; Xiaojun Zhao | Zendy; Weihong Ding | Zendy; Yuancheng Gou | Zendy; Ke Xu | Zendy; Chuanyu Sun | Zendy; Guowei Xia | Zendy

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Periostin Mediates TGF-β-Induced Epithelial Mesenchymal Transition in Prostate Cancer Cells

Author(s) -

Qingfeng Hu,

Shijun Tong,

Xiaojun Zhao,

Weihong Ding,

Yuancheng Gou,

Ke Xu,

Chuanyu Sun,

Guowei Xia

Publication year - 2015

Publication title -

cellular physiology and biochemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.486

H-Index - 87

eISSN - 1421-9778

pISSN - 1015-8987

DOI - 10.1159/000430139

Subject(s) - periostin , epithelial–mesenchymal transition , small hairpin rna , cancer research , western blot , cell growth , protein kinase b , mtt assay , downregulation and upregulation , chemistry , biology , signal transduction , microbiology and biotechnology , apoptosis , extracellular matrix , gene knockdown , biochemistry , gene

In our previous study, we found that periostin was upregulated in prostate cancer, and its expression could be modulated by TGF-β. TGF-β could upregulate periostin expression in some cells, and both TGF-β and periostin could induce epithelial mesenchymal transition (EMT). We aimed to study the effect of periostin in the process of TGF-β-induced EMT in prostate cancer cells.

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