Enhanced Suicidal Erythrocyte Death Contributing to Anemia in the Elderly | Zendy

Adrian Lupescu | Zendy; Rosi Bissinger | Zendy; T. H. H. Goebel | Zendy; Madhuri S. Salker | Zendy; Kousi Alzoubi | Zendy; Guilai Liu | Zendy; Liviu Chirigiu | Zendy; Andreas F. Mack | Zendy; Syed M. Qadri | Zendy; Florian Läng | Zendy

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Enhanced Suicidal Erythrocyte Death Contributing to Anemia in the Elderly

Author(s) -

Adrian Lupescu,

Rosi Bissinger,

T. H. H. Goebel,

Madhuri S. Salker,

Kousi Alzoubi,

Guilai Liu,

Liviu Chirigiu,

Andreas F. Mack,

Syed M. Qadri,

Florian Läng

Publication year - 2015

Publication title -

cellular physiology and biochemistry

Language(s) - English

Resource type - Journals

eISSN - 1421-9778

pISSN - 1015-8987

DOI - 10.1159/000430137

Subject(s) - ceramide , oxidative stress , reactive oxygen species , phosphatidylserine , anemia , hemoglobin , medicine , glutathione , endocrinology , red blood cell , apoptosis , senescence , chemistry , andrology , biology , biochemistry , enzyme , phospholipid , membrane

Anemia, a common condition in the elderly, could result from impaired formation and/or from accelerated loss of circulating erythrocytes. The latter could result from premature suicidal erythrocyte death or eryptosis characterized by phosphatidylserine (PS) exposure at the erythrocyte surface. Triggers of eryptosis include increased cytosolic Ca(2+)-concentration ([Ca(2+)]i), oxidative stress and ceramide. The present study explored whether eryptosis is altered in elderly individuals and, if so, to identify underlying mechanisms.

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