A Functional Variant at the miR-214 Binding Site in the Methylenetetrahydrofolatereductase Gene Alters Susceptibility to Gastric Cancer in a Chinese Han Population | Zendy

Qiaoyun Chen | Zendy; Rong Qin | Zendy; Yue Fang | Zendy; Hao Li | Zendy; Yangchen Liu | Zendy

Open Access

A Functional Variant at the miR-214 Binding Site in the Methylenetetrahydrofolatereductase Gene Alters Susceptibility to Gastric Cancer in a Chinese Han Population

Author(s) -

Qiaoyun Chen,

Rong Qin,

Yue Fang,

Hao Li,

Yangchen Liu

Publication year - 2015

Publication title -

cellular physiology and biochemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.486

H-Index - 87

eISSN - 1421-9778

pISSN - 1015-8987

DOI - 10.1159/000430125

Subject(s) - methylenetetrahydrofolate reductase , genotype , single nucleotide polymorphism , allele , biology , genetics , untranslated region , microbiology and biotechnology , microrna , cancer , gene , population , cancer research , medicine , messenger rna , environmental health

Single nucleotide polymorphisms in miRNA binding sites, which are located in mRNA 3' untranslated regions (3'-UTRs), were recently found to influence microRNA-target interactions. Specifically, such polymorphisms can modulatebinding affinity or create or destroy miRNA-binding sites; such variants have also been found to be associated with cancer risk. In this study, we explored the effect of a functional variant at the miR-214 binding site in the methylenetetrahydrofolate reductase gene (rs114673809) on gastric cancer (GC) risk in a hospital-based case-control study in a Chinese Han population.

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