Hydrogen Suppresses Hypoxia/Reoxygenation-Induced Cell Death in Hippocampal Neurons Through Reducing Oxidative Stress | Zendy

Wei Rong | Zendy; Rufang Zhang | Zendy; Yewei Xie | Zendy; Li Shen | Zendy; Fang Chen | Zendy

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Hydrogen Suppresses Hypoxia/Reoxygenation-Induced Cell Death in Hippocampal Neurons Through Reducing Oxidative Stress

Author(s) -

Wei Rong,

Rufang Zhang,

Yewei Xie,

Li Shen,

Fang Chen

Publication year - 2015

Publication title -

cellular physiology and biochemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.486

H-Index - 87

eISSN - 1421-9778

pISSN - 1015-8987

DOI - 10.1159/000430122

Subject(s) - oxidative stress , apoptosis , reactive oxygen species , hypoxia (environmental) , protein kinase b , chemistry , western blot , tunel assay , programmed cell death , caspase 3 , pharmacology , microbiology and biotechnology , biology , biochemistry , oxygen , organic chemistry , gene

Deep hypothermic circulatory arrest (DHCA) is a cerebral protection technique that has been used in the operations involving the aortic arch and brain aneurysm for decades. We previous showed that DHCA treated rats developed a significant oxidative stress and apoptosis in neurons. We here intend to investigate the protective the effect of hydrogen against oxidative stress-induced cell injury and the involved mechanisms using an in vitro experimental model of hypoxia/reoxygenation (H/R) on HT-22 cells.

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