Nesfatin-1 Suppresses Cardiac L-type Ca2+ Channels Through Melanocortin Type 4 Receptor and the Novel Protein Kinase C Theta Isoform Pathway | Zendy

Jiaoqian Ying | Zendy; Yuan Zhang | Zendy; Shan Shan Gong | Zendy; Zhigang Chang | Zendy; Xiaofeng Zhou | Zendy; Hua Li | Zendy; Jin Tao | Zendy; Guoqiang Zhang | Zendy

Open Access

Nesfatin-1 Suppresses Cardiac L-type Ca2+ Channels Through Melanocortin Type 4 Receptor and the Novel Protein Kinase C Theta Isoform Pathway

Author(s) -

Jiaoqian Ying,

Yuan Zhang,

Shan Shan Gong,

Zhigang Chang,

Xiaofeng Zhou,

Hua Li,

Jin Tao,

Guoqiang Zhang

Publication year - 2015

Publication title -

cellular physiology and biochemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.486

H-Index - 87

eISSN - 1421-9778

pISSN - 1015-8987

DOI - 10.1159/000430120

Subject(s) - protein kinase c , medicine , endocrinology , bapta , pertussis toxin , gene isoform , receptor , protein kinase a , g protein , biology , microbiology and biotechnology , chemistry , intracellular , signal transduction , kinase , biochemistry , gene

Nesfatin-1 (NF-1), an anorexic nucleobindin-2 (NUCB2)-derived hypothalamic peptide, acts as a peripheral cardiac modulator and it can induce negative inotropic effects. However, the mechanisms underlying these effects in cardiomyocytes remain unclear.

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