Fasudil Stimulates Neurite Outgrowth and Promotes Differentiation in C17.2 Neural Stem Cells by Modulating Notch Signalling but not Autophagy | Zendy

Shu Chen | Zendy; Ming Luo | Zendy; Yuming Zhao | Zendy; Yimin Zhang | Zendy; MingLiang He | Zendy; Wangqing Cai | Zendy; Anmin Liu | Zendy

Open Access

Fasudil Stimulates Neurite Outgrowth and Promotes Differentiation in C17.2 Neural Stem Cells by Modulating Notch Signalling but not Autophagy

Author(s) -

Shu Chen,

Ming Luo,

Yuming Zhao,

Yimin Zhang,

MingLiang He,

Wangqing Cai,

Anmin Liu

Publication year - 2015

Publication title -

cellular physiology and biochemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.486

H-Index - 87

eISSN - 1421-9778

pISSN - 1015-8987

DOI - 10.1159/000430118

Subject(s) - neurite , fasudil , autophagy , microbiology and biotechnology , neural stem cell , cellular differentiation , stem cell , biology , chemistry , signal transduction , rho associated protein kinase , apoptosis , biochemistry , in vitro , gene

Neurite outgrowth is one of the important therapeutic strategies for neuronal plasticity and regeneration in neural disorders. Fasudil is a clinical medication that is used to treat subarachnoid haemorrhage (SAH) and that is beneficial for many animal models of central nervous system (CNS) diseases. In this study, we hypothesised that fasudil administration would promote neurite outgrowth in neural stem cells (NSCs).

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