Ginsenoside Rh2 Inhibits Cancer Stem-Like Cells in Skin Squamous Cell Carcinoma | Zendy

Shunli Liu | Zendy; Mingrui Chen | Zendy; Pengcheng Li | Zendy; Yujia Wu | Zendy; Chunjuan Chang | Zendy; Ya-bin Qiu | Zendy; Ling Cao | Zendy; Zhen Liu | Zendy; Chiyu Jia | Zendy

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Ginsenoside Rh2 Inhibits Cancer Stem-Like Cells in Skin Squamous Cell Carcinoma

Author(s) -

Shunli Liu,

Mingrui Chen,

Pengcheng Li,

Yujia Wu,

Chunjuan Chang,

Ya-bin Qiu,

Ling Cao,

Zhen Liu,

Chiyu Jia

Publication year - 2015

Publication title -

cellular physiology and biochemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.486

H-Index - 87

eISSN - 1421-9778

pISSN - 1015-8987

DOI - 10.1159/000430115

Subject(s) - lgr5 , viability assay , autophagy , cancer stem cell , stem cell , cancer research , wnt signaling pathway , small hairpin rna , mtt assay , cell growth , cancer cell , biology , cell , chemistry , cancer , microbiology and biotechnology , signal transduction , cell culture , apoptosis , biochemistry , gene knockdown , genetics

Treatments targeting cancer stem cells (CSCs) are most effective cancer therapy, whereas determination of CSCs is challenging. We have recently reported that Lgr5-positive cells are cancer stem cells (CSCs) in human skin squamous cell carcinoma (SCC). Ginsenoside Rh2 (GRh2) has been shown to significantly inhibit growth of some types of cancers, whereas its effects on the SCC have not been examined.

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