14,15-Epoxyeicosatrienoic Acid Suppresses Cigarette Smoke Extract-Induced Apoptosis in Lung Epithelial Cells by Inhibiting Endoplasmic Reticulum Stress | Zendy

Ganggang Yu | Zendy; Xiangjun Zeng | Zendy; Hongxia Wang | Zendy; Qi Hou | Zendy; Chunting Tan | Zendy; Qiu-Fen Xu | Zendy; Haoyan Wang | Zendy

Open Access

14,15-Epoxyeicosatrienoic Acid Suppresses Cigarette Smoke Extract-Induced Apoptosis in Lung Epithelial Cells by Inhibiting Endoplasmic Reticulum Stress

Author(s) -

Ganggang Yu,

Xiangjun Zeng,

Hongxia Wang,

Qi Hou,

Chunting Tan,

Qiu-Fen Xu,

Haoyan Wang

Publication year - 2015

Publication title -

cellular physiology and biochemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.486

H-Index - 87

eISSN - 1421-9778

pISSN - 1015-8987

DOI - 10.1159/000430113

Subject(s) - epoxygenase , unfolded protein response , apoptosis , chop , endoplasmic reticulum , reactive oxygen species , oxidative stress , chemistry , cyp2e1 , p38 mitogen activated protein kinases , nox4 , viability assay , mtt assay , cytochrome p450 , blot , microbiology and biotechnology , pharmacology , cyp1b1 , mapk/erk pathway , signal transduction , biochemistry , biology , nadph oxidase , enzyme , gene

Epoxyeicosatrienoic acids (EETs), a type of lipid mediators produced by cytochrome P450 epoxygenases, exert anti-inflammatory, angiogenic, anti-oxidative and anti-apoptotic effects. However, the role of EETs in cigarette smoke-induced lung injury and the underlying mechanisms are not fully known. The aim of this study was to explore the effects of CYP2J2-EETs on cigarette smoke extracts (CSE)-induced apoptosis in human bronchial epithelial cell line (Beas-2B) and the possible mechanisms involved.

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