Anaplastic Lymphoma Kinase Immunocytochemistry on Cell-Transferred Cytologic Smears of Lung Adenocarcinoma | Zendy

Chen Zhang | Zendy; Melissa Randolph | Zendy; Kelly J. Jones | Zendy; Harvey Cramer | Zendy; Liang Cheng | Zendy; Howard H. Wu | Zendy

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Anaplastic Lymphoma Kinase Immunocytochemistry on Cell-Transferred Cytologic Smears of Lung Adenocarcinoma

Author(s) -

Chen Zhang,

Melissa Randolph,

Kelly J. Jones,

Harvey Cramer,

Liang Cheng,

Howard H. Wu

Publication year - 2015

Publication title -

acta cytologica

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.513

H-Index - 57

eISSN - 1938-2650

pISSN - 0001-5547

DOI - 10.1159/000430083

Subject(s) - anaplastic lymphoma kinase , staining , pathology , medicine , papanicolaou stain , fluorescence in situ hybridization , adenocarcinoma , immunohistochemistry , stain , lung cancer , cytology , biopsy , fine needle aspiration , cancer , biology , biochemistry , cervical cancer , gene , malignant pleural effusion , chromosome

Anaplastic lymphoma kinase (ALK) immunohistochemical staining on formalin-fixed paraffin-embedded tissue or cell blocks (CB) has been reported as an effective alternative to fluorescence hybridization in situ (FISH) for the detection of ALK gene rearrangement. However, CB frequently lack adequate cellularity even when the direct smears are cellular. This study aims to assess the utility of ALK immunocytochemical (ICC) staining on direct smears using the cell transfer (CT) technique for the detection of ALK rearrangement.

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