Urine and Plasma Osmolality in Patients with Autosomal Dominant Polycystic Kidney Disease: Reliable Indicators of Vasopressin Activity and Disease Prognosis? | Zendy

Niek F. Casteleijn | Zendy; Debbie Zittema | Zendy; Stephan J. L. Bakker | Zendy; Wendy E. Boertien | Zendy; Sandrine Gaillard | Zendy; Esther Meijer | Zendy; Edwin M. Spithoven | Zendy; Joachim Struck | Zendy; Ron T. Gansevoort | Zendy

Open Access

Urine and Plasma Osmolality in Patients with Autosomal Dominant Polycystic Kidney Disease: Reliable Indicators of Vasopressin Activity and Disease Prognosis?

Author(s) -

Niek F. Casteleijn,

Debbie Zittema,

Stephan J. L. Bakker,

Wendy E. Boertien,

Sandrine Gaillard,

Esther Meijer,

Edwin M. Spithoven,

Joachim Struck,

Ron T. Gansevoort

Publication year - 2015

Publication title -

american journal of nephrology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.394

H-Index - 85

eISSN - 1421-9670

pISSN - 0250-8095

DOI - 10.1159/000382081

Subject(s) - copeptin , urine osmolality , plasma osmolality , medicine , vasopressin , endocrinology , urine , autosomal dominant polycystic kidney disease , renal function , urology , kidney

Vasopressin plays an essential role in osmoregulation, but has deleterious effects in patients with ADPKD. Increased water intake to suppress vasopressin activity has been suggested as a potential renoprotective strategy. This study investigated whether urine and plasma osmolality can be used as reflection of vasopressin activity in ADPKD patients.

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