High Titer Anti-Basement Membrane Antibodies in a Subset of Patients with Pediatric Systemic Lupus Erythematosus | Zendy

Alvaro Orjuela | Zendy; Adisak Suwanichkul | Zendy; Debra Canter | Zendy; Charles G. Minard | Zendy; Sridevi Devaraj | Zendy; John Hicks | Zendy; Eyal Muscal | Zendy; Scott E. Wenderfer | Zendy

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High Titer Anti-Basement Membrane Antibodies in a Subset of Patients with Pediatric Systemic Lupus Erythematosus

Author(s) -

Alvaro Orjuela,

Adisak Suwanichkul,

Debra Canter,

Charles G. Minard,

Sridevi Devaraj,

John Hicks,

Eyal Muscal,

Scott E. Wenderfer

Publication year - 2015

Publication title -

american journal of nephrology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.394

H-Index - 85

eISSN - 1421-9670

pISSN - 0250-8095

DOI - 10.1159/000381965

Subject(s) - medicine , lupus nephritis , immunology , antibody , titer , gastroenterology , disease

There is a critical need for more noninvasive biomarkers to identify nephritis in patients with systemic lupus erythematosus (SLE). Recent studies in a model mouse and an adult SLE patient cohort suggest that anti-basement membrane antibody levels correlate well with lupus activity and kidney injury. The purpose of this study was to assess the anti-basement membrane reactivity in pediatric SLE (pSLE) patients with or without nephritis.

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