Genetics and Epigenetics of Diabetic Nephropathy | Zendy

Ruijie Liu | Zendy; Kyung Lee | Zendy; John Cijiang He | Zendy

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Genetics and Epigenetics of Diabetic Nephropathy

Author(s) -

Ruijie Liu,

Kyung Lee,

John Cijiang He

Publication year - 2015

Publication title -

kidney diseases

Language(s) - English

Resource type - Journals

eISSN - 2296-9381

pISSN - 2296-9357

DOI - 10.1159/000381796

Subject(s) - epigenetics , biology , dna methylation , microrna , population , genetics , disease , diabetic nephropathy , genome wide association study , bioinformatics , gene , medicine , single nucleotide polymorphism , genotype , kidney , gene expression , environmental health

Diabetic nephropathy (DN) is the most common cause of end-stage renal disease (ESRD) in the USA and worldwide, contributing to significant morbidity and mortality in diabetic patients. A genetic factor for the development of DN is strongly implicated, as only one third of diabetic patients eventually develop kidney disease. Growing evidence also supports an important role of epigenetic modifications in DN.

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