Hypoxia and Dysregulated Angiogenesis in Kidney Disease | Zendy

Shinji Tanaka | Zendy; Tetsuhiro Tanaka | Zendy; Masaomi Nangaku | Zendy

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Hypoxia and Dysregulated Angiogenesis in Kidney Disease

Author(s) -

Shinji Tanaka,

Tetsuhiro Tanaka,

Masaomi Nangaku

Publication year - 2015

Publication title -

kidney diseases

Language(s) - English

Resource type - Journals

eISSN - 2296-9381

pISSN - 2296-9357

DOI - 10.1159/000381515

Subject(s) - angiogenesis , kidney disease , kidney , vascular endothelial growth factor , hypoxia (environmental) , medicine , hypoxia inducible factors , acute kidney injury , pathogenesis , cancer research , endocrinology , immunology , biology , chemistry , vegf receptors , organic chemistry , oxygen , biochemistry , gene

Accumulating evidence has demonstrated that renal hypoxia has a crucial role in the pathogenesis of acute kidney injury (AKI), chronic kidney disease (CKD), and AKI-to-CKD transition, ultimately culminating in end-stage kidney disease. Renal hypoxia in progressive CKD is intricately linked to persisting capillary loss, which is mainly due to dysregulated angiogenesis.

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