MST-312 Alters Telomere Dynamics, Gene Expression Profiles and Growth in Human Breast Cancer Cells | Zendy

Resham L Gurung | Zendy; Shi Ni Lim | Zendy; Grace Kah Mun Low | Zendy; M. Prakash Hande | Zendy

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MST-312 Alters Telomere Dynamics, Gene Expression Profiles and Growth in Human Breast Cancer Cells

Author(s) -

Resham L Gurung,

Shi Ni Lim,

Grace Kah Mun Low,

M. Prakash Hande

Publication year - 2014

Publication title -

lifestyle genomics

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.542

H-Index - 30

eISSN - 2504-3188

pISSN - 2504-3161

DOI - 10.1159/000381346

Subject(s) - telomere , telomerase , microbiology and biotechnology , dna damage , cancer research , breast cancer , biology , cancer cell , dna repair , cancer , chemistry , gene , dna , genetics

Targeting telomerase is a potential cancer management strategy given that it allows unlimited cellular replication in the majority of cancers. Dysfunctional telomeres are recognized as double-strand breaks. However, the status of DNA repair response pathways following telomerase inhibition is not well understood in human breast cancer cells. Here, we evaluated the effects of MST-312, a chemically modified derivative from tea catechin, epigallocatechin gallate, on telomere dynamics and DNA damage gene expression in breast cancer cells.

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