Urine Metabolomics by 1H-NMR Spectroscopy Indicates Associations between Serum 3,5-T2 Concentrations and Intermediary Metabolism in Euthyroid Humans | Zendy

Maik Pietzner | Zendy; Georg Homuth | Zendy; Kathrin Budde | Zendy; Ina Lehmphul | Zendy; Uwe Völker | Zendy; Henry Völzke | Zendy; Matthias Nauck | Zendy; Josef Köhrle | Zendy; Nele Friedrich | Zendy

Open Access

Urine Metabolomics by 1H-NMR Spectroscopy Indicates Associations between Serum 3,5-T2 Concentrations and Intermediary Metabolism in Euthyroid Humans

Author(s) -

Maik Pietzner,

Georg Homuth,

Kathrin Budde,

Ina Lehmphul,

Uwe Völker,

Henry Völzke,

Matthias Nauck,

Josef Köhrle,

Nele Friedrich

Publication year - 2015

Publication title -

european thyroid journal

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.23

H-Index - 10

eISSN - 2235-0802

pISSN - 2235-0640

DOI - 10.1159/000381308

Subject(s) - medicine , endocrinology , euthyroid , metabolite , urine , trigonelline , metabolome , population , lipid metabolism , urinary system , hormone , chemistry , biochemistry , environmental health

3,5-Diiodo-L-thyronine (3,5-T2) is a thyroid hormone metabolite which exhibited versatile effects in rodent models, including the prevention of insulin resistance or hepatic steatosis typically forced by a high-fat diet. With respect to euthyroid humans, we recently observed a putative link between serum 3,5-T2 and glucose but not lipid metabolism.

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