VPS13D Gene Variant Is Associated with Altered IL-6 Production and Mortality in Septic Shock | Zendy

Takaaki Nakada | Zendy; John H. Boyd | Zendy; James A. Russell | Zendy; Rosalía Aguirre-Hernández | Zendy; Mark D. Wilkinson | Zendy; Simone A. Thair | Zendy; Emiri Nakada | Zendy; Melissa K. McConechy | Zendy; Christopher D. Fjell | Zendy; Keith R. Walley | Zendy

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<b><i>VPS13D</i></b> Gene Variant Is Associated with Altered IL-6 Production and Mortality in Septic Shock

Author(s) -

Takaaki Nakada,

John H. Boyd,

James A. Russell,

Rosalía Aguirre-Hernández,

Mark D. Wilkinson,

Simone A. Thair,

Emiri Nakada,

Melissa K. McConechy,

Christopher D. Fjell,

Keith R. Walley

Publication year - 2015

Publication title -

journal of innate immunity

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.078

H-Index - 64

eISSN - 1662-8128

pISSN - 1662-811X

DOI - 10.1159/000381265

Subject(s) - genome wide association study , septic shock , biology , genotype , allele , locus (genetics) , genetic association , genetics , gene , microbiology and biotechnology , immunology , single nucleotide polymorphism , sepsis

Genetic variations contribute to septic shock mortality. To discover a novel locus, we performed in vitro genome-wide association studies (GWAS) and further tested the result in a cohort of septic shock patients.

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