Effects of Age and Estradiol on Gene Expression in the Rhesus Macaque Hypothalamus | Zendy

Dominique H. Eghlidi | Zendy; Henryk F. Urbanski | Zendy

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Effects of Age and Estradiol on Gene Expression in the Rhesus Macaque Hypothalamus

Author(s) -

Dominique H. Eghlidi,

Henryk F. Urbanski

Publication year - 2015

Publication title -

neuroendocrinology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.493

H-Index - 101

eISSN - 1423-0194

pISSN - 0028-3835

DOI - 10.1159/000381063

Subject(s) - endocrinology , medicine , estrogen , hypothalamus , biology , kisspeptin , ovariectomized rat , rhesus macaque , estrogen receptor alpha , macaque , estrogen receptor , neurokinin b , neuropeptide , receptor , neuroscience , substance p , genetics , cancer , breast cancer

The hypothalamus plays a key role in mediating the effects of estrogen on many physiological functions, including reproduction, metabolism, and thermoregulation. We have previously observed marked estrogen-dependent gene expression changes within the hypothalamus of rhesus macaques during aging, especially in the KNDy neurons of the arcuate-median eminence (ARC-ME) that produce kisspeptin, neurokinin B, and dynorphin A. Little is known, however, about the mechanisms involved in mediating the feedback from estrogen onto these neurons.

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