Long-Term Exposure to House Dust Mite Leads to the Suppression of Allergic Airway Disease Despite Persistent Lung Inflammation | Zendy

Sonali J. Bracken | Zendy; Alexander J. Adami | Zendy; Steven M. Szczepanek | Zendy; Mohsin Ehsan | Zendy; P Natarajan | Zendy; Linda Guernsey | Zendy; Neda Shahriari | Zendy; Ektor Rafti | Zendy; Adam Matson | Zendy; Craig M. Schramm | Zendy; Roger S. Thrall | Zendy

Open Access

Long-Term Exposure to House Dust Mite Leads to the Suppression of Allergic Airway Disease Despite Persistent Lung Inflammation

Author(s) -

Sonali J. Bracken,

Alexander J. Adami,

Steven M. Szczepanek,

Mohsin Ehsan,

P Natarajan,

Linda Guernsey,

Neda Shahriari,

Ektor Rafti,

Adam Matson,

Craig M. Schramm,

Roger S. Thrall

Publication year - 2015

Publication title -

international archives of allergy and immunology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.696

H-Index - 100

eISSN - 1423-0097

pISSN - 1018-2438

DOI - 10.1159/000381058

Subject(s) - immunology , house dust mite , medicine , bronchoalveolar lavage , eosinophilia , inflammation , asthma , allergic inflammation , pulmonary eosinophilia , allergy , immune system , foxp3 , lung , allergen , eosinophil

Allergic asthma is a major cause of worldwide morbidity and results from inadequate immune regulation in response to innocuous, environmental antigens. The need exists to understand the mechanisms that promote nonreactivity to human-relevant allergens such as house dust mite (HDM) in order to develop curative therapies for asthma. The aim of our study was to compare the effects of short-, intermediate- and long-term HDM administration in a murine asthma model and determine the ability of long-term HDM exposure to suppress allergic inflammation.

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