Colorectal Cancer: Personalized Therapy | Zendy

Jonas Leichsenring | Zendy; Adriane Koppelle | Zendy; Anke ReinacherSchick | Zendy

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Colorectal Cancer: Personalized Therapy

Author(s) -

Jonas Leichsenring,

Adriane Koppelle,

Anke ReinacherSchick

Publication year - 2014

Publication title -

gastrointestinal tumors

Language(s) - English

Resource type - Journals

eISSN - 2296-3766

pISSN - 2296-3774

DOI - 10.1159/000380790

Subject(s) - microsatellite instability , colorectal cancer , kras , medicine , oncology , neuroblastoma ras viral oncogene homolog , dna mismatch repair , targeted therapy , epidermal growth factor receptor , cancer , precision medicine , disease , pathology , biology , biochemistry , allele , microsatellite , gene

Colorectal cancer (CRC) is the second most common type of cancer in the Western world. The treatment of this disease has evolved greatly, particularly for patients with metastatic disease. The advent of combination chemotherapy plus targeted agents has led to more curative resections and improved survival rates in these patients. A deeper understanding of the mechanisms of tumorigenesis has facilitated tumor characterization, prognosis and patient stratification, bringing us one step closer towards personalized medicine.

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