Update on the Autoimmune Pathology of Multiple Sclerosis: B-Cells as Disease-Drivers and Therapeutic Targets | Zendy

H.Christian von Büdingen | Zendy; Arumugam Palanichamy | Zendy; Klaus LehmannHorn | Zendy; Brady Michel | Zendy; Scott S. Zamvil | Zendy

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Update on the Autoimmune Pathology of Multiple Sclerosis: B-Cells as Disease-Drivers and Therapeutic Targets

Author(s) -

H.Christian von Büdingen,

Arumugam Palanichamy,

Klaus LehmannHorn,

Brady Michel,

Scott S. Zamvil

Publication year - 2015

Publication title -

european neurology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.573

H-Index - 77

eISSN - 1421-9913

pISSN - 0014-3022

DOI - 10.1159/000377675

Subject(s) - immunology , cd19 , b cell , immunotherapy , antibody , cd20 , biology , antigen , monoclonal antibody , medicine , cancer research , immune system

Collectively, research on the role of B-cells in the pathogenesis of multiple sclerosis (MS) illustrates how translational medicine has given rise to promising therapeutic approaches for one of the most debilitating chronic neurological diseases in young adults. First described in 1935, the experimental autoimmune/allergic encephalomyelitis model is a key animal model that has provided the foundation for important developments in targeted therapeutics.

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