The Effectiveness of Preoperative Trimetazidine on Myocardial Preservation in Coronary Artery Bypass Graft Patients: A Systematic Review and Meta-Analysis | Zendy

Nan Zhang | Zendy; Jiayan Lei | Zendy; Qing Liu | Zendy; Wei Huang | Zendy; Hua Xiao | Zendy; Han Lei | Zendy

Open Access

The Effectiveness of Preoperative Trimetazidine on Myocardial Preservation in Coronary Artery Bypass Graft Patients: A Systematic Review and Meta-Analysis

Author(s) -

Nan Zhang,

Jiayan Lei,

Qing Liu,

Wei Huang,

Hua Xiao,

Han Lei

Publication year - 2015

Publication title -

cardiology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.547

H-Index - 63

eISSN - 1421-9751

pISSN - 0008-6312

DOI - 10.1159/000375289

Subject(s) - trimetazidine , medicine , cardiology , creatine kinase , coronary artery disease , artery , ischemia , creatine , troponin t , troponin , randomized controlled trial , troponin i , myocardial infarction

Coronary artery bypass grafting (CABG) is a key and effective surgical treatment modality for coronary artery disease. Unfortunately, ischemia-reperfusion injury during and after CABG can lead to reversible and irreversible myocardial damage. Trimetazidine [1-(2,3,4-trimethoxybenzyl)piperazine dihydrochloride] is a metabolic anti-ischemic agent with demonstrated cardioprotective effects; however, its effects with respect to myocardial preservation in CABG patients remain unclear.

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