Tetramethylpyrazine Ameliorated Hypoxia-Induced Myocardial Cell Apoptosis via HIF-1α/JNK/p38 and IGFBP3/BNIP3 Inhibition to Upregulate PI3K/Akt Survival Signaling | Zendy

KuanHo Lin | Zendy; WeiWen Kuo | Zendy; Ai-Zhi Jiang | Zendy; PeiYing Pai | Zendy; Jing-Ying Lin | Zendy; Wei-Kung Chen | Zendy; Cecilia Hsuan Day | Zendy; Chia-Yao Shen | Zendy; V. Vijaya Padma | Zendy; ChihYang Huang | Zendy

Open Access

Tetramethylpyrazine Ameliorated Hypoxia-Induced Myocardial Cell Apoptosis via HIF-1α/JNK/p38 and IGFBP3/BNIP3 Inhibition to Upregulate PI3K/Akt Survival Signaling

Author(s) -

KuanHo Lin,

WeiWen Kuo,

Ai-Zhi Jiang,

PeiYing Pai,

Jing-Ying Lin,

Wei-Kung Chen,

Cecilia Hsuan Day,

Chia-Yao Shen,

V. Vijaya Padma,

ChihYang Huang

Publication year - 2015

Publication title -

cellular physiology and biochemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.486

H-Index - 87

eISSN - 1421-9778

pISSN - 1015-8987

DOI - 10.1159/000374076

Subject(s) - pi3k/akt/mtor pathway , protein kinase b , tetramethylpyrazine , apoptosis , hypoxia (environmental) , p38 mitogen activated protein kinases , downregulation and upregulation , programmed cell death , chemistry , microbiology and biotechnology , pharmacology , medicine , kinase , biology , protein kinase a , biochemistry , pathology , oxygen , alternative medicine , organic chemistry , gene

Hemorrhagic shock (HS) is the major cause of death from trauma. Hemorrhagic shock may lead to cellular hypoxia and organ damage. Our previous findings showed that HS induced a cardiac apoptosis pathway and synergistically caused myocardial cell damage in diabetic rats under trauma-induced HS. Tetramethylpyrazine (TMP) is a major biologically active ingredient purified from the rhizome of Ligusticum wallichii (called Chuang Xiong in Chinese). Chuan Xiong rescued cells from synergistic cardiomyoblast cell injury under high-glucose (HG) conditions plus hypoxia. TMP is one of the most important active ingredients that elevated the survival rate in ischemic brain injury and prevented inducible NO synthase expression to have anti-inflammatory effects against cell damage in different cell types.

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