Cinnamaldehyde Prevents Endothelial Dysfunction Induced by High Glucose by Activating Nrf2 | Zendy

Fang Wang | Zendy; Chunhua Pu | Zendy; Peng Zhou | Zendy; Peijian Wang | Zendy; Dengpan Liang | Zendy; Qiulin Wang | Zendy; Yonghe Hu | Zendy; BingHu Li | Zendy; Xinzhong Hao | Zendy

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Cinnamaldehyde Prevents Endothelial Dysfunction Induced by High Glucose by Activating Nrf2

Author(s) -

Fang Wang,

Chunhua Pu,

Peng Zhou,

Peijian Wang,

Dengpan Liang,

Qiulin Wang,

Yonghe Hu,

BingHu Li,

Xinzhong Hao

Publication year - 2015

Publication title -

cellular physiology and biochemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.486

H-Index - 87

eISSN - 1421-9778

pISSN - 1015-8987

DOI - 10.1159/000374074

Subject(s) - endothelial dysfunction , oxidative stress , reactive oxygen species , chemistry , peroxynitrite , nitrotyrosine , nitric oxide , pharmacology , endothelium , catalase , reactive nitrogen species , biochemistry , endocrinology , medicine , nitric oxide synthase , superoxide , enzyme , organic chemistry

It is well documented that hyperglycemia-induced oxidative stress is an important causative factor of endothelial dysfunction. Cinnamaldehyde (CA) is a key flavor compound in cinnamon essential oil that can enhance the antioxidant defense against reactive oxygen species (ROS) by activating NF-E2-related factor 2 (Nrf2), which has been shown to have a cardiovascular protective effect, but its role in endothelial dysfunction induced by high glucose is unknown.

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