The Functional Variant in the 3'UTR of PTPRT with the Risk of Esophageal Squamous Cell Carcinoma in a Chinese Population | Zendy

Yongliang Yao | Zendy; Jie Shao | Zendy; Jian Wu | Zendy; Qinghui Zhang | Zendy; Jianjun Wang | Zendy; Daping Xiao | Zendy; Feng Huang | Zendy

Open Access

The Functional Variant in the 3'UTR of PTPRT with the Risk of Esophageal Squamous Cell Carcinoma in a Chinese Population

Author(s) -

Yongliang Yao,

Jie Shao,

Jian Wu,

Qinghui Zhang,

Jianjun Wang,

Daping Xiao,

Feng Huang

Publication year - 2015

Publication title -

cellular physiology and biochemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.486

H-Index - 87

eISSN - 1421-9778

pISSN - 1015-8987

DOI - 10.1159/000374073

Subject(s) - single nucleotide polymorphism , biology , microrna , genotype , snp , population , cancer research , carcinogenesis , oncology , genetics , medicine , cancer , bioinformatics , gene , environmental health

PTPRT is an essential tumor suppressor that plays crucial roles in regulating the mechanisms of tumorigenesis. Polymorphisms in PTPRT have been reported associated with human longevity, but their association with the risk of esophageal squamous cell carcinoma (ESCC) has not been found so far. In this study, we focused on the miRNAs associated SNPs in the 3'-UTR of PTPRT to investigate the further relationship of the SNPs with miRNAs among Chinese ESCC patients.

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