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Polymorphisms located at microRNA (miRNA) binding sites may interfere with the miRNA/mRNA interaction. The objective of this study was to identify the association between a single nucleotide polymorphism (774 T&gt;C) in 3'-untranslated region (3'-UTR) of Epithelial Growth Factor Receptor (EGFR) and development of pulmonary hypertension (PH) in chronic obstructive pulmonary disease (COPD) as well as to explore the molecular mechanism.

cellular physiology and biochemistry

A Single Nucleotide Polymorphism in 3' Untranslated Region of Epithelial Growth Factor Receptor Confers Risk for Pulmonary Hypertension in Chronic Obstructive Pulmonary Disease