A Single Nucleotide Polymorphism in 3' Untranslated Region of Epithelial Growth Factor Receptor Confers Risk for Pulmonary Hypertension in Chronic Obstructive Pulmonary Disease | Zendy

Sijing Zhou | Zendy; Min� Li | Zendy; Daxiong Zeng | Zendy; Xuan Xu | Zendy; Liming Fei | Zendy; Qingqing Zhu | Zendy; Yan Zhang | Zendy; Ran Wang | Zendy

Open Access

A Single Nucleotide Polymorphism in 3' Untranslated Region of Epithelial Growth Factor Receptor Confers Risk for Pulmonary Hypertension in Chronic Obstructive Pulmonary Disease

Author(s) -

Sijing Zhou,

Min� Li,

Daxiong Zeng,

Xuan Xu,

Liming Fei,

Qingqing Zhu,

Yan Zhang,

Ran Wang

Publication year - 2015

Publication title -

cellular physiology and biochemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.486

H-Index - 87

eISSN - 1421-9778

pISSN - 1015-8987

DOI - 10.1159/000374061

Subject(s) - single nucleotide polymorphism , genotype , copd , untranslated region , epidermal growth factor receptor , microrna , three prime untranslated region , allele , biology , medicine , receptor , cancer research , gene , messenger rna , genetics

Polymorphisms located at microRNA (miRNA) binding sites may interfere with the miRNA/mRNA interaction. The objective of this study was to identify the association between a single nucleotide polymorphism (774 T>C) in 3'-untranslated region (3'-UTR) of Epithelial Growth Factor Receptor (EGFR) and development of pulmonary hypertension (PH) in chronic obstructive pulmonary disease (COPD) as well as to explore the molecular mechanism.

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