HIF-1α as a Regulator of BMP2-Induced Chondrogenic Differentiation, Osteogenic Differentiation, and Endochondral Ossification in Stem Cells | Zendy

Nian Zhou | Zendy; Ning Hu | Zendy; Junyi Liao | Zendy; Liangbo Lin | Zendy; Chen Zhao | Zendy; Weike Si | Zendy; Zhong Yang | Zendy; Shixiong Yi | Zendy; Tingxu Fan | Zendy; Wei Bao | Zendy; Xi Liang | Zendy; Wei Xu | Zendy; Hong Chen | Zendy; Cheng Chen | Zendy; Qiang Chen | Zendy; Xin Lin | Zendy; Wei Huang | Zendy

Open Access

HIF-1α as a Regulator of BMP2-Induced Chondrogenic Differentiation, Osteogenic Differentiation, and Endochondral Ossification in Stem Cells

Author(s) -

Nian Zhou,

Ning Hu,

Junyi Liao,

Liangbo Lin,

Chen Zhao,

Weike Si,

Zhong Yang,

Shixiong Yi,

Tingxu Fan,

Wei Bao,

Xi Liang,

Wei Xu,

Hong Chen,

Cheng Chen,

Qiang Chen,

Xin Lin,

Wei Huang

Publication year - 2015

Publication title -

cellular physiology and biochemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.486

H-Index - 87

eISSN - 1421-9778

pISSN - 1015-8987

DOI - 10.1159/000374052

Subject(s) - endochondral ossification , chondrogenesis , bone morphogenetic protein 2 , microbiology and biotechnology , chondrocyte , cartilage , mesenchymal stem cell , stem cell , ossification , cellular differentiation , chemistry , biology , anatomy , in vitro , biochemistry , gene

Joint cartilage defects are difficult to treat due to the limited self-repair capacities of cartilage. Cartilage tissue engineering based on stem cells and gene enhancement is a potential alternative for cartilage repair. Bone morphogenetic protein 2 (BMP2) has been shown to induce chondrogenic differentiation in mesenchymal stem cells (MSCs); however, maintaining the phenotypes of MSCs during cartilage repair since differentiation occurs along the endochondral ossification pathway. In this study, hypoxia inducible factor, or (HIF)-1α, was determined to be a regulator of BMP2-induced chondrogenic differentiation, osteogenic differentiation, and endochondral bone formation.

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