Pre-Eclampsia-Associated Reduction in Placental Growth Factor Impaired Beta Cell Proliferation Through PI3k Signalling | Zendy

Jun Li | Zendy; Huanchun Ying | Zendy; Guiyang Cai | Zendy; Quan Guo | Zendy; Lizhu Chen | Zendy

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Pre-Eclampsia-Associated Reduction in Placental Growth Factor Impaired Beta Cell Proliferation Through PI3k Signalling

Author(s) -

Jun Li,

Huanchun Ying,

Guiyang Cai,

Quan Guo,

Lizhu Chen

Publication year - 2015

Publication title -

cellular physiology and biochemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.486

H-Index - 87

eISSN - 1421-9778

pISSN - 1015-8987

DOI - 10.1159/000374051

Subject(s) - placental growth factor , cell growth , pi3k/akt/mtor pathway , cell cycle , endocrinology , medicine , mapk/erk pathway , growth factor , microbiology and biotechnology , chemistry , biology , cell , cancer research , kinase , signal transduction , vascular endothelial growth factor , receptor , biochemistry , vegf receptors

Reduction in serum placental growth factor (PLGF) frequently co-occurs with preeclampsia (PE) and gestational diabetes mellitus (GDM). Recently, we reported that impairment in gestational beta-cell mass growth may result from PE-associated reduction in PLGF and lead to development of GDM. Here, we studied the underlying mechanisms.

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