Activation in M1 but not M2 Macrophages Contributes to Cardiac Remodeling after Myocardial Infarction in Rats: a Critical Role of the Calcium Sensing Receptor/NRLP3 Inflammasome | Zendy

Wenxiu Liu | Zendy; Xin Zhang | Zendy; Meng Zhao | Zendy; Xiaohui Zhang | Zendy; Jinyu Chi | Zendy; Yue Liu | Zendy; Fang Lin | Zendy; Yu Fu | Zendy; Dandan Ma | Zendy; Xinhua Yin | Zendy

Open Access

Activation in M1 but not M2 Macrophages Contributes to Cardiac Remodeling after Myocardial Infarction in Rats: a Critical Role of the Calcium Sensing Receptor/NRLP3 Inflammasome

Author(s) -

Wenxiu Liu,

Xin Zhang,

Meng Zhao,

Xiaohui Zhang,

Jinyu Chi,

Yue Liu,

Fang Lin,

Yu Fu,

Dandan Ma,

Xinhua Yin

Publication year - 2015

Publication title -

cellular physiology and biochemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.486

H-Index - 87

eISSN - 1421-9778

pISSN - 1015-8987

DOI - 10.1159/000374048

Subject(s) - calcium sensing receptor , inflammasome , receptor , medicine , endocrinology , fibrosis , cardiac fibrosis , inflammation , blot , downregulation and upregulation , ventricular remodeling , chemistry , calcium , myocardial infarction , calcium metabolism , biochemistry , gene

Macrophage (MΦ) infiltration during myocardial infarction (MI) amplifies cardiac inflammation and remodeling. We investigated whether activation of the NRLP3 inflammasome by a calcium sensing receptor (CaSR) in MΦ subsets contributes to cardiac remodeling following MI.

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