Angiotensin-(1-7) Attenuates Angiotensin II-Induced ICAM-1, VCAM-1, and MCP-1 Expression via the MAS Receptor Through Suppression of P38 and NF-κB Pathways in HUVECs | Zendy

Bin Liang | Zendy; Xin Wang | Zendy; Nana Zhang | Zendy; Huiyu Yang | Zendy; Rui Bai | Zendy; Ming Liu | Zendy; Yunfei Bian | Zendy; Xiao Chuan-shi | Zendy; Zhiming Yang | Zendy

Open Access

Angiotensin-(1-7) Attenuates Angiotensin II-Induced ICAM-1, VCAM-1, and MCP-1 Expression via the MAS Receptor Through Suppression of P38 and NF-κB Pathways in HUVECs

Author(s) -

Bin Liang,

Xin Wang,

Nana Zhang,

Huiyu Yang,

Rui Bai,

Ming Liu,

Yunfei Bian,

Xiao Chuan-shi,

Zhiming Yang

Publication year - 2015

Publication title -

cellular physiology and biochemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.486

H-Index - 87

eISSN - 1421-9778

pISSN - 1015-8987

DOI - 10.1159/000374047

Subject(s) - p38 mitogen activated protein kinases , vcam 1 , angiotensin ii , mapk/erk pathway , nf κb , umbilical vein , icam 1 , signal transduction , chemistry , receptor , endocrinology , microbiology and biotechnology , medicine , biology , cell adhesion molecule , biochemistry , in vitro

Atherosclerosis is a chronic inflammatory disease. Intracellular adhesion molecule-1 (ICAM-1), vascular cellular adhesion molecule-1 (VCAM-1), and monocyte chemoattractant protein-1 (MCP-1) play important roles in inflammatory processes. P38 mitogen-activated protein kinase (MAPK) and nuclear factor (NF)-κB signaling regulate ICAM-1, VCAM-1, and MCP-1 expression. Angiotensin (Ang) II upregulates ICAM-1, VCAM-1, and MCP-1 expression through the P38 MAPK and NF-κB pathways. Ang-(1-7) may oppose the actions of Ang II. We investigated whether Ang-(1-7) prevents Ang II-induced ICAM-1, VCAM-1, and MCP-1 expression in human umbilical vein endothelial cells (HUVECs).

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