Salicylate Inhibits Thrombopoiesis in Rat Megakaryocytes by Changing the Membrane Micro-Architecture | Zendy

Itsuro Kazama | Zendy; Asuka Baba | Zendy; Yasuhiro Endo | Zendy; Hiroaki Toyama | Zendy; Yutaka Ejima | Zendy; Mitsunobu Matsubara | Zendy; Masahiro Tachi | Zendy

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Salicylate Inhibits Thrombopoiesis in Rat Megakaryocytes by Changing the Membrane Micro-Architecture

Author(s) -

Itsuro Kazama,

Asuka Baba,

Yasuhiro Endo,

Hiroaki Toyama,

Yutaka Ejima,

Mitsunobu Matsubara,

Masahiro Tachi

Publication year - 2015

Publication title -

cellular physiology and biochemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.486

H-Index - 87

eISSN - 1421-9778

pISSN - 1015-8987

DOI - 10.1159/000374039

Subject(s) - thrombopoiesis , megakaryocyte , membrane , platelet , microbiology and biotechnology , biophysics , chemistry , haematopoiesis , cell membrane , biochemistry , biology , immunology , stem cell

Salicylate causes drug-induced immune thrombocytopenia. However, some clinical studies indicate the presence of additional mechanisms in the drug-induced thrombocytopenia, by which the platelet production from megakaryocytes may directly be affected. Since salicylate is amphiphilic and preferentially partitioned into the lipid bilayers of the plasma membrane, it can induce some structural changes in the megakaryocyte membrane surface and thus affect the process of thrombopoiesis.

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