Nicorandil Protects the Heart from Ischemia/Reperfusion Injury by Attenuating Endoplasmic Reticulum Response-induced Apoptosis Through PI3K/Akt Signaling Pathway | Zendy

Hui Wu | Zendy; Ming Ye | Zendy; H. J. Yang | Zendy; Jiawang Ding | Zendy; Jian Yang | Zendy; Wusong Dong | Zendy; Xinan Wang | Zendy

Open Access

Nicorandil Protects the Heart from Ischemia/Reperfusion Injury by Attenuating Endoplasmic Reticulum Response-induced Apoptosis Through PI3K/Akt Signaling Pathway

Author(s) -

Hui Wu,

Ming Ye,

H. J. Yang,

Jiawang Ding,

Jian Yang,

Wusong Dong,

Xinan Wang

Publication year - 2015

Publication title -

cellular physiology and biochemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.486

H-Index - 87

eISSN - 1421-9778

pISSN - 1015-8987

DOI - 10.1159/000374035

Subject(s) - wortmannin , nicorandil , unfolded protein response , cardioprotection , endoplasmic reticulum , pi3k/akt/mtor pathway , protein kinase b , pharmacology , medicine , tunicamycin , apoptosis , reperfusion injury , endocrinology , chemistry , ischemia , microbiology and biotechnology , biology , biochemistry

As a vasodilatory drug used to treat angina, nicorandil has been shown to induce an infarct-limiting effect in various experimental animal models of myocardial ischemia-reperfusion (IR). There are multiple mechanisms causing the IR injury, among which, the endoplasmic reticulum (ER) stress and ER stress-initiated apoptosis are implicated to play an important role. However, whether ER stress is involved in nicorandil-induced cardioprotection is unknown.

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