Exendin-4 Promotes Beta Cell Proliferation via PI3k/Akt Signalling Pathway | Zendy

Chaoxun Wang | Zendy; Xiaopan Chen | Zendy; Xiaoying Ding | Zendy; Yan-ju He | Zendy; Chengying Gu | Zendy; Ligang Zhou | Zendy

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Exendin-4 Promotes Beta Cell Proliferation via PI3k/Akt Signalling Pathway

Author(s) -

Chaoxun Wang,

Xiaopan Chen,

Xiaoying Ding,

Yan-ju He,

Chengying Gu,

Ligang Zhou

Publication year - 2015

Publication title -

cellular physiology and biochemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.486

H-Index - 87

eISSN - 1421-9778

pISSN - 1015-8987

DOI - 10.1159/000374027

Subject(s) - cell growth , pi3k/akt/mtor pathway , microbiology and biotechnology , beta cell , beta (programming language) , mapk/erk pathway , protein kinase b , cell , biology , in vivo , signal transduction , chemistry , endocrinology , biochemistry , insulin , genetics , islet , computer science , programming language

Prevention of diabetes requires maintenance of a functional beta-cell mass, the postnatal growth of which depends on beta cell proliferation. Past studies have shown evidence of an effect of an incretin analogue, Exendin-4, in promoting beta cell proliferation, whereas the underlying molecular mechanisms are not completely understood.

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