Modulation of Pulmonary Vascular Remodeling in Hypoxia: Role of 15-LOX-2/15-HETE-MAPKs Pathway | Zendy

Xiufeng Yu | Zendy; Tingting Li | Zendy; Xia Liu | Zendy; Hao Yu | Zendy; Zhongfei Hao | Zendy; Yingli Chen | Zendy; Chen Zhang | Zendy; Yumei Liu | Zendy; Qian Li | Zendy; Min Mao | Zendy; Daling Zhu | Zendy

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Modulation of Pulmonary Vascular Remodeling in Hypoxia: Role of 15-LOX-2/15-HETE-MAPKs Pathway

Author(s) -

Xiufeng Yu,

Tingting Li,

Xia Liu,

Hao Yu,

Zhongfei Hao,

Yingli Chen,

Chen Zhang,

Yumei Liu,

Qian Li,

Min Mao,

Daling Zhu

Publication year - 2015

Publication title -

cellular physiology and biochemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.486

H-Index - 87

eISSN - 1421-9778

pISSN - 1015-8987

DOI - 10.1159/000374015

Subject(s) - tunel assay , apoptosis , mapk/erk pathway , kinase , hypoxia (environmental) , p38 mitogen activated protein kinases , cell growth , cell cycle , biology , terminal deoxynucleotidyl transferase , microbiology and biotechnology , chemistry , biochemistry , organic chemistry , oxygen

We have previously shown that 15-hydroxyeicosatetraenoic acid (15-HETE) plays a critical role in pulmonary hypertension (PH)-associated vascular remodeling. However, the signaling mechanisms remain unclear. The purpose of this study was to investigate the role of 15-lipoxygenase-2 (15-LO-2)/15-HETE-mitogen-activated protein kinases (MAPKs) pathway in hypoxia-induced pulmonary vascular remodeling and the underlying mechanisms.

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