Genistein Inhibits Human Colorectal Cancer Growth and Suppresses MiR-95, Akt and SGK1 | Zendy

Jian Qin | Zendy; Jia Xin Chen | Zendy; Zhou Zhu | Zendy; Jia An Teng | Zendy

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Genistein Inhibits Human Colorectal Cancer Growth and Suppresses MiR-95, Akt and SGK1

Author(s) -

Jian Qin,

Jia Xin Chen,

Zhou Zhu,

Jia An Teng

Publication year - 2015

Publication title -

cellular physiology and biochemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.486

H-Index - 87

eISSN - 1421-9778

pISSN - 1015-8987

DOI - 10.1159/000374013

Subject(s) - genistein , protein kinase b , pi3k/akt/mtor pathway , cancer research , cell growth , apoptosis , phosphorylation , western blot , chemistry , biology , microbiology and biotechnology , endocrinology , biochemistry , gene

Genistein, a major isoflavonoid isolated from dietary soybean, has been shown to suppress the growth of several cancers through modulation of various pathways. However, the molecular mechanisms by which genistein elicit its effects on colorectal cancer (CRC) cells have not been fully elucidated. In this study, we aimed to investigate the anti-tumor activities of genistein on CRC and its potential mechanism.

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