Cochlear NMDA Receptors as a Therapeutic Target of Noise-Induced Tinnitus | Zendy

Dan Bing | Zendy; Sze Chim Lee | Zendy; Dario Campanelli | Zendy; Hao Xiong | Zendy; Masahiro Matsumoto | Zendy; Rama Panford-Walsh | Zendy; Stephan Wolpert | Zendy; Mark Praetorius | Zendy; Ulrike Zimmermann | Zendy; Hanqi Chu | Zendy; Marlies Knipper | Zendy; Lukas Rüttiger | Zendy; Wibke Singer | Zendy

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Cochlear NMDA Receptors as a Therapeutic Target of Noise-Induced Tinnitus

Author(s) -

Dan Bing,

Sze Chim Lee,

Dario Campanelli,

Hao Xiong,

Masahiro Matsumoto,

Rama Panford-Walsh,

Stephan Wolpert,

Mark Praetorius,

Ulrike Zimmermann,

Hanqi Chu,

Marlies Knipper,

Lukas Rüttiger,

Wibke Singer

Publication year - 2015

Publication title -

cellular physiology and biochemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.486

H-Index - 87

eISSN - 1421-9778

pISSN - 1015-8987

DOI - 10.1159/000374000

Subject(s) - tinnitus , cochlea , nmda receptor , medicine , auditory brainstem response , round window , hair cell , neuroscience , cochlear nerve , brainstem , audiology , hearing loss , receptor , psychology

Accumulating evidence suggests that tinnitus may occur despite normal auditory sensitivity, probably linked to partial degeneration of the cochlear nerve and damage of the inner hair cell (IHC) synapse. Damage to the IHC synapses and deafferentation may occur even after moderate noise exposure. For both salicylate- and noise-induced tinnitus, aberrant N-methyl-d-aspartate (NMDA) receptor activation and related auditory nerve excitation have been suggested as origin of cochlear tinnitus. Accordingly, NMDA receptor inhibition has been proposed as a pharmacologic approach for treatment of synaptopathic tinnitus.

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