Wear Particles Promote Reactive Oxygen Species-Mediated Inflammation via the Nicotinamide Adenine Dinucleotide Phosphate Oxidase Pathway in Macrophages Surrounding Loosened Implants | Zendy

Weishen Chen | Zendy; Ziqing Li | Zendy; Ying Guo | Zendy; Yuhuan Zhou | Zendy; Ziji Zhang | Zendy; Yangchun Zhang | Zendy; Guotian Luo | Zendy; Xing Yang | Zendy; WeiMing Liao | Zendy; Chaohong Li | Zendy; Lingwu Chen | Zendy; Puyi Sheng | Zendy

Open Access

Wear Particles Promote Reactive Oxygen Species-Mediated Inflammation via the Nicotinamide Adenine Dinucleotide Phosphate Oxidase Pathway in Macrophages Surrounding Loosened Implants

Author(s) -

Weishen Chen,

Ziqing Li,

Ying Guo,

Yuhuan Zhou,

Ziji Zhang,

Yangchun Zhang,

Guotian Luo,

Xing Yang,

WeiMing Liao,

Chaohong Li,

Lingwu Chen,

Puyi Sheng

Publication year - 2015

Publication title -

cellular physiology and biochemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.486

H-Index - 87

eISSN - 1421-9778

pISSN - 1015-8987

DOI - 10.1159/000373996

Subject(s) - apocynin , nicotinamide adenine dinucleotide phosphate , nadph oxidase , reactive oxygen species , inflammation , chemistry , oxidative stress , lipopolysaccharide , oxidase test , microbiology and biotechnology , biochemistry , immunology , enzyme , biology

Prosthesis loosening is closely associated with chronic inflammatory cytokine secretion by macrophages, which are activated by wear particles or inflammatory stimulants such as lipopolysaccharide (LPS). Reactive oxygen species (ROS) are critical regulators of inflammation, but their enzymatic sources in response to wear particles and their effects on peri-implant LPS-tolerance remain unclear.

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