Cinnamaldehyde Derivative (CB-PIC) Sensitizes Chemo-Resistant Cancer Cells to Drug-Induced Apoptosis via Suppression of MDR1 and its Upstream STAT3 and AKT Signalling | Zendy

Jianzhong Xi | Zendy; Miyong Yun | Zendy; Duckgue Lee | Zendy; Moon Nyeo Park | Zendy; EunOk Kim | Zendy; Eun Jung Sohn | Zendy; Byung-Mog Kwon | Zendy

Open Access

Cinnamaldehyde Derivative (CB-PIC) Sensitizes Chemo-Resistant Cancer Cells to Drug-Induced Apoptosis via Suppression of MDR1 and its Upstream STAT3 and AKT Signalling

Author(s) -

Jianzhong Xi,

Miyong Yun,

Duckgue Lee,

Moon Nyeo Park,

EunOk Kim,

Eun Jung Sohn,

Byung-Mog Kwon

Publication year - 2015

Publication title -

cellular physiology and biochemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.486

H-Index - 87

eISSN - 1421-9778

pISSN - 1015-8987

DOI - 10.1159/000373993

Subject(s) - protein kinase b , cancer cell , apoptosis , chemistry , microbiology and biotechnology , survivin , mtt assay , cancer research , biology , cancer , biochemistry , genetics

Our group reported that cinnamaldehyde derivative, (E)-4-((2-(3-oxopop-1-enyl)phenoxy)methyl)pyridinium malonic acid (CB-PIC) induced apoptosis in hypoxic SW620 colorectal cancer cells via activation of AMP-activated protein kinase (AMPK) and extracellular signal regulated kinase (ERK). Herein, sensitizing effect of CB-PIC was investigated in resistant cancer cells such as paclitaxel (PT) resistant lung cancer cells (H460/PT), and Adriamycin (Adr) resistant breast cancer (MCF7/Adr) and colon cancer (HCT15/cos) cells.

The content you want is available to Zendy users.

Already have an account? Click here to sign in.

Having issues? You can contact us here

Accelerating Research