Inhibition of Ocular Neovascularization by Co-Inhibition of VEGF-A and PLGF | Zendy

Xiaochuan Huo | Zendy; Youxiang Li | Zendy; Yuhua Jiang | Zendy; Xiaoyun Sun | Zendy; Lixue Gu | Zendy; Wenshi Guo | Zendy; Dapeng Sun | Zendy

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Inhibition of Ocular Neovascularization by Co-Inhibition of VEGF-A and PLGF

Author(s) -

Xiaochuan Huo,

Youxiang Li,

Yuhua Jiang,

Xiaoyun Sun,

Lixue Gu,

Wenshi Guo,

Dapeng Sun

Publication year - 2015

Publication title -

cellular physiology and biochemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.486

H-Index - 87

eISSN - 1421-9778

pISSN - 1015-8987

DOI - 10.1159/000373990

Subject(s) - choroidal neovascularization , macular degeneration , vascular endothelial growth factor , neovascularization , angiogenesis , placental growth factor , inflammation , macrophage , retinopathy of prematurity , medicine , cancer research , immunology , vascular endothelial growth factor a , biology , vegf receptors , ophthalmology , in vitro , biochemistry , pregnancy , genetics , gestational age

Age-related macular degeneration (AMD) appears to be a disease with increasing incidence in Western countries and may develop into acquired blindness. Choroidal neovascularization (CNV) is the most frequent cause for AMD, and is commonly induced by regional inflammation. Past studies have highlighted vascular endothelial growth factor A (VEGF-A) as a major trigger for CNV. However, studies on the associated angiogenic factors other than VEGF-A are lacking.

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