Open AccessNuclear SMAD2 Restrains Proliferation of Glioblastoma
Author(s) -
Yunhu Yu,
Qishan Ran
Publication year - 2015
Publication title -
cellular physiology and biochemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.486
H-Index - 87
eISSN - 1421-9778
pISSN - 1015-8987
DOI - 10.1159/000373987
Subject(s) - glioblastoma , cancer research , cell growth , medicine , neuroscience , biology , microbiology and biotechnology , genetics
Although TGFβ receptor signaling has been shown to play a role in regulation of the growth and metastasis of glioblastoma multiforme (GBM), the downstream pathway through either SMAD2 or SMAD3 has not been elucidated. In this study, we investigate whether nuclear SMAD2 can restrain the proliferation of glioblastoma.
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