Anti-Inflammatory Effects of Tanshinone IIA on Atherosclerostic Vessels of Ovariectomized ApoE-/- Mice are Mediated by Estrogen Receptor Activation and Through the ERK Signaling Pathway | Zendy

Xin Liu | Zendy; Chun-yu Guo | Zendy; Xiaojuan Ma | Zendy; Caifeng Wu | Zendy; Ying Zhang | Zendy; Mingyue Sun | Zendy; Yuting Pan | Zendy; Hui-jun Yin | Zendy

Open Access

Anti-Inflammatory Effects of Tanshinone IIA on Atherosclerostic Vessels of Ovariectomized ApoE-/- Mice are Mediated by Estrogen Receptor Activation and Through the ERK Signaling Pathway

Author(s) -

Xin Liu,

Chun-yu Guo,

Xiaojuan Ma,

Caifeng Wu,

Ying Zhang,

Mingyue Sun,

Yuting Pan,

Hui-jun Yin

Publication year - 2015

Publication title -

cellular physiology and biochemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.486

H-Index - 87

eISSN - 1421-9778

pISSN - 1015-8987

DOI - 10.1159/000373986

Subject(s) - ovariectomized rat , endocrinology , medicine , estrogen receptor , estrogen , apolipoprotein e , chemistry , disease , cancer , breast cancer

Estrogen plays a protective role in atherosclerosis. Our preliminary work demonstrated that the active conformation of Tanshinone IIA(TanIIA) is similar to the 17β-estradiol and it can bind to the estrogen receptor. Here, we hypothesized that Tanshinone IIA might have anti-inflammatory and anti-oxidative effects in atherosclerosis, mediated through estrogen receptor activation.

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